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KMID : 0602720140180020120
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Implantology
2014 Volume.18 No. 2 p.120 ~ p.138
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Development of Scaffold for Cell Attachment and Evaluation of Tissue Regeneration Using Stem Cells Seeded Scaffold
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You Hoon
Song Kyung-Ho
Lim Hyun-Chang
Lee Jung-Seok
Yun Jeong-Ho
Seo Young-Kwon
Jung Ui-Won
Lee Yong-Keun
Oh Nam-Sik
Choi Seong-Ho
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Abstract
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Purpose: The purpose of this study was to review the outcomes of a series of studies on tissue regeneration conducted in multiple institutions including the Department of Periodontology, College of Dentistry, Yonsei University.
Materials and Methods: Studies were performed divided into the following three subjects; 1) Development of three-dimensional nano-hydroxyapatite (n-HA) scaffold for facilitating drug release and cell adhesion. 2) Synergistic effects of bone marrow-derived mesenchymal stem cells (BMMSC) application simultaneously with platelet-rich plasma (PRP) on HA scaffolds. 3) The efficacy of silk scaffolds coated with n-HA. Also, all results were analyzed by subjects.
Results: Hollow hydroxyapatite spherical granules were found to be a useful tool for the drug release and avidin-biotin binding system for cell attachment. Also, BMMSC simultaneously with PRP applied in an animal bone defect model was seen to be more synergistic than in the control group. But, the efficacy of periodontal ligament cells and dental pulp cells with silk scaffolds could not be confirmed in the initial phase of bone healing.
Conclusion: The ideal combination of three elements of tissue engineering?scaffolds, cells and signaling molecules could be substantiated due to further investigations with the potentials and limitations of the suggested list of studies.
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KEYWORD
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stem cells, tissue engineering, tissue scaffolds
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